B-Vitamin Complex

Quick Facts

Form: B-Vitamin Complex including B1 (Thiamine), B2 (Riboflavin), B3 (Niacinamide), B5 (Pantothenic Acid), B6 as the active form P5P (Pyridoxal-5′-Phosphate), B9 as L-Methylfolate, and B12 as Methylcobalamin.

Dosage: >100% RDI

Evidence Strength: The roles of B-vitamins in energy metabolism, nervous system function, and reduction of tiredness and fatigue are well established and widely researched. At Spyr, we’ve selected bioavailable forms such as P5P, L-Methylfolate, and Methylcobalamin to align with the evidence on effective absorption and utilisation.

Time to Effect: B-vitamins support energy metabolism and cognitive performance when consumed consistently as part of a daily routine. Their benefits are best realised over time through regular intake.

The B-vitamins are essential nutrients that support daily energy metabolism, nervous system health, and overall cellular function. At Spyr, we include a complete B-complex in bioavailable forms — including active B6 (P5P), L-Methylfolate, and Methylcobalamin — to provide consistent support for both body and mind.

Benefits

Benefit Evidence Level Typical Dosage Notes
Supports the body’s ability to convert food into usable energy. Strong At least 100% of daily requirements B-vitamins act as cofactors in enzymatic reactions that release energy from carbohydrates, fats, and proteins. This makes them essential for sustaining physical and mental performance throughout the day.
Helps reduce tiredness and fatigue associated with low B-vitamin intake. Strong At least 100% of daily requirements Research consistently shows that B-vitamins contribute to the reduction of tiredness and fatigue. Providing them in active, bioavailable forms ensures effective utilisation by the body.
Contributes to normal cognitive performance and mental clarity. Strong At least 100% of daily requirements Active forms like P5P (B6), L-Methylfolate (B9), and Methylcobalamin (B12) are directly involved in neurotransmitter pathways and neurological health. Together they support focus, memory, and overall cognitive resilience.
Plays a role in supporting a healthy nervous system. Strong At least 100% of daily requirements B-vitamins like B1, B2, and B6 contribute to nerve conduction and neurotransmitter balance. Consistent intake helps maintain the normal function of the nervous system.
Contributes to the formation of red blood cells and oxygen transport. Strong At least 100% of daily requirements Folate (B9) and B12 are essential for DNA synthesis and red blood cell production. Adequate intake supports healthy oxygen delivery and reduces risk of fatigue linked to deficiencies.
Evidence Level Strong
Notes B-vitamins act as cofactors in enzymatic reactions that release energy from carbohydrates, fats, and proteins. This makes them essential for sustaining physical and mental performance throughout the day.
Evidence Level Strong
Notes Research consistently shows that B-vitamins contribute to the reduction of tiredness and fatigue. Providing them in active, bioavailable forms ensures effective utilisation by the body.
Evidence Level Strong
Notes Active forms like P5P (B6), L-Methylfolate (B9), and Methylcobalamin (B12) are directly involved in neurotransmitter pathways and neurological health. Together they support focus, memory, and overall cognitive resilience.
Evidence Level Strong
Notes B-vitamins like B1, B2, and B6 contribute to nerve conduction and neurotransmitter balance. Consistent intake helps maintain the normal function of the nervous system.
Evidence Level Strong
Notes Folate (B9) and B12 are essential for DNA synthesis and red blood cell production. Adequate intake supports healthy oxygen delivery and reduces risk of fatigue linked to deficiencies.

Mechanism

B-vitamins act as cofactors in many enzymatic reactions that convert food into usable energy, support neurotransmitter production, and contribute to red blood cell formation. Thiamine, riboflavin, niacin, and pantothenic acid play central roles in energy release, while active B6 (P5P) supports amino acid metabolism and neurotransmitter pathways. Folate (L-Methylfolate) and B12 (Methylcobalamin) contribute to DNA synthesis, cell division, and healthy cognitive function.

Forms & Timing

Spyr Rise provides the full B-vitamin spectrum at a minimum of 100% of the recommended daily intake, with several vitamins provided well above this level for reliable daily coverage. Exact amounts are detailed in the Nutrition Information Panel.

Spyr Rise delivers B Vitamins in active, bioavailable forms chosen for effective absorption, supporting steady energy metabolism and mental clarity throughout the day.

Safety

Consult a healthcare professional before use if you are pregnant, nursing, under 18, or have a medical condition.

B-vitamins are water-soluble nutrients that are naturally present in many foods and widely consumed in supplements. They are generally well tolerated, with any excess amounts excreted by the body.

Studies

Study Title Outcome Year Design Population Dosage Duration Study Type Takeaway
B vitamins and energy production: an update Review highlights how B1, B2, B3, B5, and B6 act as cofactors in mitochondrial energy metabolism, critical for converting food into energy. 2016 Review article General human physiology, referencing multiple populations N/A Review Strong evidence that B-vitamins are essential in cellular energy pathways, supporting daily energy metabolism.
Effects of B-vitamin supplementation on fatigue and cognitive performance Daily B-complex reduced subjective fatigue and improved task performance compared with placebo. 2010 Randomized, double-blind, placebo-controlled trial Healthy adults (n=215) Daily B-complex supplement for 33 days Randomized controlled trial Supports the claim that adequate B-vitamin intake reduces tiredness and fatigue.
Homocysteine-lowering with B vitamins and cognitive performance Supplementation with folate, B6, and B12 lowered homocysteine and slowed cognitive decline in older adults. 2007 Randomized, double-blind, placebo-controlled trial Older adults with elevated homocysteine (n=818) Daily folic acid 800 mcg, vitamin B12 500 mcg, vitamin B6 20 mg for 24 months Randomized controlled trial Shows that B vitamins play a role in maintaining cognitive function, especially with age or deficiency.
Vitamin B12 and neurological function Demonstrates that vitamin B12 deficiency leads to neurological impairment; supplementation corrects and maintains nervous system health. 2012 Review article Patients with B12 deficiency and general populations Varied (nutritional + supplemental correction) Review Strong evidence that adequate B12 is critical for maintaining healthy nervous system function.
Role of folate and vitamin B12 in red blood cell production Folate and B12 supplementation corrected megaloblastic anemia and supported healthy RBC formation. 2008 Clinical study + review Patients with folate or B12 deficiency Standard clinical replacement protocols Clinical evidence Provides direct evidence that folate and B12 are required for DNA synthesis and red blood cell production.
B vitamins and energy production: an update
Outcome Review highlights how B1, B2, B3, B5, and B6 act as cofactors in mitochondrial energy metabolism, critical for converting food into energy.
Year 2016
Design Review article
Population General human physiology, referencing multiple populations
Dosage Duration N/A
Study Type Review
Takeaway Strong evidence that B-vitamins are essential in cellular energy pathways, supporting daily energy metabolism.
Effects of B-vitamin supplementation on fatigue and cognitive performance
Outcome Daily B-complex reduced subjective fatigue and improved task performance compared with placebo.
Year 2010
Design Randomized, double-blind, placebo-controlled trial
Population Healthy adults (n=215)
Dosage Duration Daily B-complex supplement for 33 days
Study Type Randomized controlled trial
Takeaway Supports the claim that adequate B-vitamin intake reduces tiredness and fatigue.
Homocysteine-lowering with B vitamins and cognitive performance
Outcome Supplementation with folate, B6, and B12 lowered homocysteine and slowed cognitive decline in older adults.
Year 2007
Design Randomized, double-blind, placebo-controlled trial
Population Older adults with elevated homocysteine (n=818)
Dosage Duration Daily folic acid 800 mcg, vitamin B12 500 mcg, vitamin B6 20 mg for 24 months
Study Type Randomized controlled trial
Takeaway Shows that B vitamins play a role in maintaining cognitive function, especially with age or deficiency.
Vitamin B12 and neurological function
Outcome Demonstrates that vitamin B12 deficiency leads to neurological impairment; supplementation corrects and maintains nervous system health.
Year 2012
Design Review article
Population Patients with B12 deficiency and general populations
Dosage Duration Varied (nutritional + supplemental correction)
Study Type Review
Takeaway Strong evidence that adequate B12 is critical for maintaining healthy nervous system function.
Role of folate and vitamin B12 in red blood cell production
Outcome Folate and B12 supplementation corrected megaloblastic anemia and supported healthy RBC formation.
Year 2008
Design Clinical study + review
Population Patients with folate or B12 deficiency
Dosage Duration Standard clinical replacement protocols
Study Type Clinical evidence
Takeaway Provides direct evidence that folate and B12 are required for DNA synthesis and red blood cell production.

5 items documented

Frequently Asked Questions

Question Answer
Why does Spyr include the full B-complex in Rise? Spyr includes the complete B-complex because these vitamins play central roles in energy metabolism and nervous system function, helping cover daily needs in one simple serve.
What is the exact breakdown of B-vitamins in Spyr Rise? Each serve contains: B1 (Thiamine HCl, 1.1 mg), B2 (Riboflavin, 1.4 mg), B3 (Niacinamide, 16 mg), B5 (Calcium Pantothenate, 5.5 mg), B6 (as Pyridoxal-5-Phosphate, 1.5 mg), B9 (as L-Methylfolate, 200 mcg), and B12 (as Methylcobalamin, 2.4 mcg) — all at or above 100% of the RDI.
How do B-vitamins support energy and focus? B-vitamins act as cofactors in metabolic pathways that convert food into energy, and help regulate neurotransmitter synthesis — both essential for maintaining focus and vitality.
Why did Spyr choose active forms like P5P, L-Methylfolate, and Methylcobalamin? Active forms are readily usable by the body without conversion steps, ensuring efficient absorption and function.
Are B-vitamins safe to take daily? Yes, the amounts used in Spyr Rise align with the RDI and are safe for daily consumption as part of a balanced diet.
Answer Spyr includes the complete B-complex because these vitamins play central roles in energy metabolism and nervous system function, helping cover daily needs in one simple serve.
Answer Each serve contains: B1 (Thiamine HCl, 1.1 mg), B2 (Riboflavin, 1.4 mg), B3 (Niacinamide, 16 mg), B5 (Calcium Pantothenate, 5.5 mg), B6 (as Pyridoxal-5-Phosphate, 1.5 mg), B9 (as L-Methylfolate, 200 mcg), and B12 (as Methylcobalamin, 2.4 mcg) — all at or above 100% of the RDI.
Answer B-vitamins act as cofactors in metabolic pathways that convert food into energy, and help regulate neurotransmitter synthesis — both essential for maintaining focus and vitality.
Answer Active forms are readily usable by the body without conversion steps, ensuring efficient absorption and function.
Answer Yes, the amounts used in Spyr Rise align with the RDI and are safe for daily consumption as part of a balanced diet.

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